Oxidative Stress in Diabetic Retinopathy
نویسندگان
چکیده
Diabetic Retinopathy (DR) is a progressive asymptomatic neuro-vascular complication of diabetes that triggers irreversible retinal damage [...]
منابع مشابه
Oxidative Stress and Diabetic Retinopathy
Oxygen metabolism is essential for sustaining aerobic life, and normal cellular homeostasis works on a fine balance between the formation and elimination of reactive oxygen species (ROS). Oxidative stress, a cytopathic consequence of excessive production of ROS and the suppression of ROS removal by antioxidant defense system, is implicated in the development of many diseases, including Alzheime...
متن کاملOxidative stress in diabetic patients with retinopathy.
BACKGROUND Diabetes mellitus (DM) is known to induce oxidative stress along with deranging various metabolisms; one of the late complications of diabetes mellitus is diabetic retinopathy, which is a leading cause of acquired blindness. Poor glycemic control and oxidative stress have been attributed to the development of complications like diabetic retinopathy. The aim of this study was to analy...
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Diabetic retinopathy (DR) is a major cause of blindness in working age adults, and oxidative stress plays a vital role in the pathogenesis of DR. Pigment-epithelium-derived factor (PEDF), a multifunctional protein, has shown to inhibit the development of DR by accumulating evidence. This paper highlights the current understanding of probable mechanism about how PEDF blocks the deterioration of ...
متن کاملOxidative Stress-Related Mechanisms and Antioxidant Therapy in Diabetic Retinopathy
Diabetic retinopathy (DR) is one of the most common microvascular complications of diabetes and is the leading cause of blindness in young adults. Oxidative stress has been implicated as a critical cause of DR. Metabolic abnormalities induced by high-glucose levels are involved in the development of DR and appear to be influenced by oxidative stress. The imbalance between reactive oxygen specie...
متن کاملOxidative Stress, Epigenetics, Environment, and Epidemiology of Diabetic Retinopathy
1Stem Cells and Eye Research Laboratory, Department of Ophthalmology, Faculty of Medicine, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary 2Centre of Eye Research, Department of Ophthalmology, Oslo University Hospital and University of Oslo, Oslo, Norway 3Department of Ophthalmology, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland 4Facul...
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ژورنال
عنوان ژورنال: Antioxidants
سال: 2021
ISSN: ['2076-3921']
DOI: https://doi.org/10.3390/antiox10010050